Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 5/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637330 | 0.81 | FFAR1 (0.43) | FFAR1IDO1KMT2A | |
| SCHEMBL4637258 | 0.79 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7425987 | 0.77 | SMPD1 (0.47) | IDO1 | |
| SCHEMBL7425979 | 0.76 | NPC1 (0.43) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4637252 | 0.75 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4637286 | 0.75 | ALDH1A1 (0.51) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14032377 | 0.73 | ACHE (0.51) | SLC6A4KMT2A | |
| Hydrochloric Acid SCHEMBL5117534 | 0.72 | ACHE (0.50) | SLC6A4KMT2A | |
| SCHEMBL8707317 | 0.71 | NR1H3 (0.51) | PDE4APDE4BPDE4CPDE4DNOX1 | |
| SCHEMBL11998990 | 0.70 | FFAR1 (0.60) | FFAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |