Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28321078 | 0.98 | ATM (0.32) | L3MBTL1ALDH1A1PARP1SMN1; SMN2NPC1 | |
| SCHEMBL1954054 | 0.82 | ALDH1A1 (0.41) | ALDH1A1PARP1SMN1; SMN2CYP2B6HSD11B1 | |
| SCHEMBL4637127 | 0.82 | ALDH1A1 (0.41) | ALDH1A1PARP1SMN1; SMN2CYP2B6HSD11B1 | |
| SCHEMBL3635465 | 0.81 | L3MBTL1 (0.37) | L3MBTL1ALDH1A1PARP1SMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL9698155 | 0.79 | L3MBTL1 (0.35) | L3MBTL1ALDH1A1PARP1SMN1; SMN2NPC1 | |
| SCHEMBL385731 | 0.79 | ALDH1A1 (0.38) | ALDH1A1CYP2B6DPP4CYP2C19CHRM3 | |
| SCHEMBL29184814 | 0.78 | HPGD (0.38) | KMT2ACHRM3 | |
| SCHEMBL3634948 | 0.78 | LMNA (0.36) | L3MBTL1ALDH1A1PARP1SMN1; SMN2CYP2B6 | |
| SCHEMBL4109208 | 0.77 | ATM (0.35) | L3MBTL1ALDH1A1PARP1SMN1; SMN2NPC1 | |
| SCHEMBL4104348 | 0.74 | ATM (0.36) | L3MBTL1ALDH1A1PARP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |