Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 10/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731118 | 0.80 | SFRP1 (0.48) | SFRP1RBP4 | |
| SCHEMBL4638272 | 0.80 | SFRP1 (0.59) | SFRP1ALDH1A1KDM4ERBP4 | |
| SCHEMBL4730690 | 0.78 | SFRP1 (1.00) | SFRP1 | |
| SCHEMBL4637352 | 0.76 | SFRP1 (0.63) | SFRP1 | |
| SCHEMBL4637488 | 0.75 | PIK3CA (0.47) | SFRP1KDM4EPIK3CAPIK3C3 | |
| SCHEMBL4638020 | 0.73 | HTR2A (0.47) | SFRP1 | |
| SCHEMBL4618262 | 0.72 | SFRP1 (1.00) | SFRP1 | |
| SCHEMBL4618663 | 0.69 | ALDH1A1 (0.78) | SFRP1ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL4618172 | 0.68 | ALDH1A1 (0.64) | SFRP1ALDH1A1KDM4EPOLBHPGD | |
| SCHEMBL29944351 | 0.67 | HPGD (1.00) | ALDH1A1KDM4EPOLBHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |