SCHEMBL46377

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL10534314	1.00	HCAR2 (0.50)	HCAR2KEAP1NFE2L2PPARGMAPT
	SCHEMBL28645015	1.00	HCAR2 (0.50)	HCAR2KEAP1NFE2L2PPARGMAPT
	SCHEMBL17334530	0.88	PPARG (0.48)	HCAR2KEAP1NFE2L2PPARGMAPT
	SCHEMBL28549553	0.84	PPARG (0.57)	PPARGMAPTALDH1A1CYP19A1OXER1
	SCHEMBL3017777	0.84	PPARG (0.57)	PPARGMAPTALDH1A1CYP19A1OXER1
	SCHEMBL11745554	0.84	PPARG (0.57)	PPARGMAPTALDH1A1CYP19A1OXER1
	SCHEMBL810920	0.83	AKT1 (0.54)	HCAR2KEAP1NFE2L2MAPTALDH1A1
	SCHEMBL28152408	0.83	AKT1 (0.54)	HCAR2KEAP1NFE2L2MAPTALDH1A1
	SCHEMBL810921	0.83	AKT1 (0.54)	HCAR2KEAP1NFE2L2MAPTALDH1A1
	SCHEMBL21802620	0.82	PPARG (0.43)	PPARGMAPTALDH1A1CYP19A1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.