Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637854 | 0.83 | LMNA (0.53) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL27208789 | 0.79 | ERCC5 (0.53) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL5239206 | 0.78 | ALDH1A1 (0.56) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL11449999 | 0.77 | PPARG (0.43) | MEN1LMNAKMT2AMAPT | |
| SCHEMBL7339923 | 0.77 | RAB9A (0.55) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL4637935 | 0.75 | RAB9A (0.58) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL11650545 | 0.75 | ERCC5 (0.53) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL12617736 | 0.74 | NPC1 (0.60) | NPC1ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL22304993 | 0.73 | ALDH1A1 (0.38) | NPC1ERCC5FEN1ALDH1A1RAB9A | |
| SCHEMBL2544901 | 0.73 | ERCC5 (0.47) | NPC1ERCC5FEN1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |