Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.36 |
| ▸ | SLC2A4 | P14672 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RORB | Q92753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637750 | 0.94 | IDH1 (0.43) | IDH1GRM2P2RX7SMN1; SMN2MAPT | |
| SCHEMBL4637712 | 0.93 | IDH1 (0.51) | IDH1SLC2A1SLC2A3SLC2A4GRM2 | |
| SCHEMBL4637948 | 0.92 | RORB (0.36) | IDH1GRM2GPBAR1P2RX7TACR1 | |
| SCHEMBL4638051 | 0.91 | ALDH1A1 (0.39) | GRM2GAATACR1SMN1; SMN2MAPT | |
| SCHEMBL4637811 | 0.91 | GRM2 (0.36) | IDH1GRM2GPBAR1GAATACR1 | |
| SCHEMBL4638808 | 0.89 | P2RX7 (0.38) | IDH1P2RX7SMN1; SMN2F2MAPT | |
| SCHEMBL4637883 | 0.88 | P2RX7 (0.35) | IDH1GRM2GPBAR1P2RX7TACR1 | |
| SCHEMBL4638903 | 0.86 | IDH1 (0.38) | IDH1SLC2A1SLC2A3SLC2A4KDR | |
| SCHEMBL4638576 | 0.85 | IDH1 (0.41) | IDH1KDRGPBAR1GAATACR1 | |
| SCHEMBL4637984 | 0.84 | TACR1 (0.39) | GRM2GAAP2RX7TACR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |