Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637922 | 0.94 | TACR1 (0.36) | ALDH1A1EPAS1MAPTTSHRNLRP3 | |
| SCHEMBL4672009 | 0.93 | ALDH1A1 (0.35) | ALDH1A1TDP1L3MBTL1EPAS1MAPT | |
| SCHEMBL4637945 | 0.89 | EPAS1 (0.37) | ALDH1A1EPAS1MAPTTSHRNLRP3 | |
| SCHEMBL4637694 | 0.88 | EPAS1 (0.39) | ALDH1A1TDP1L3MBTL1EPAS1MAPT | |
| SCHEMBL4637876 | 0.88 | EPAS1 (0.39) | ALDH1A1TDP1L3MBTL1EPAS1MAPT | |
| SCHEMBL4638045 | 0.87 | EPAS1 (0.39) | ALDH1A1TDP1L3MBTL1EPAS1MAPT | |
| SCHEMBL4637796 | 0.87 | EPAS1 (0.39) | ALDH1A1TDP1L3MBTL1EPAS1MAPT | |
| SCHEMBL4639398 | 0.86 | KMT2A (0.37) | ALDH1A1TDP1L3MBTL1MAPTTSHR | |
| SCHEMBL4637843 | 0.86 | GPBAR1 (0.38) | ALDH1A1L3MBTL1EPAS1MAPTTSHR | |
| SCHEMBL4639495 | 0.86 | TACR1 (0.31) | ALDH1A1TDP1L3MBTL1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |