Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639774 | 0.89 | MGAM (0.38) | MAPTNPC1SMN1; SMN2ABCB1KDM4E | |
| SCHEMBL4639483 | 0.87 | KDM4E (0.44) | MAPTNPC1SMN1; SMN2KDM4EUSP2 | |
| SCHEMBL4640568 | 0.85 | PDE4A (0.43) | S1PR1S1PR3 | |
| SCHEMBL4639813 | 0.82 | S1PR1 (0.43) | MAPTNPC1S1PR1S1PR3KDM4E | |
| SCHEMBL4639690 | 0.81 | MAPT (0.43) | MAPTNPC1SMN1; SMN2ABCB1KDM4E | |
| SCHEMBL4277625 | 0.81 | LMNA (0.36) | MAPTNPC1SMN1; SMN2S1PR1S1PR3 | |
| SCHEMBL4280728 | 0.80 | GSK3B (0.41) | NPC1KDM4ELMNA | |
| SCHEMBL4639429 | 0.80 | KDM4E (0.37) | MAPTNPC1SMN1; SMN2KDM4EUSP2 | |
| SCHEMBL5592943 | 0.78 | LMNA (0.34) | LMNA | |
| SCHEMBL4640544 | 0.78 | PIK3CG (0.42) | MAPTNPC1SMN1; SMN2ABCB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A9 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |