Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.55 |
| ▸ | FAAH | O00519 | 4/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014433 | 0.91 | MAPT (0.51) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL4578069 | 0.89 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL8121430 | 0.89 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL5450752 | 0.89 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL12101788 | 0.89 | MAPT (0.50) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL4580230 | 0.89 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL8115352 | 0.89 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL8652814 | 0.87 | MGLL (0.47) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL371216 | 0.86 | MGLL (0.70) | MGLLFAAHPTGS1PTGS2ALDH1A1 | |
| SCHEMBL5570285 | 0.86 | MGLL (0.50) | MGLLFAAHPTGS1PTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101180269-A | Process for preparing 3-cyano-quinolines and intermediates prepared therefrom | WYETH CORP (US) | 2008-05-14 | — | — | CN | disclosed |
| EP-1883621-A2 | METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY | Wyeth (US) | 2008-02-06 | — | — | EP | disclosed |
| WO-2006127205-A3 | METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY | WYETH CORP (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20060270669-A1 | Method of preparing 3-cyano-quinolines and intermediates made thereby | WYETH | 2006-11-30 | — | — | US | disclosed |
| WO-2006127205-A2 | METHODS OF PREPARING 3-CYANO-QUINOLINES AND INTERMEDIATES MADE THEREBY | WYETH (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270669-A1 | Method of preparing 3-cyano-quinolines and intermediates made thereby | CNP, PPP4C, PTMS | MGLL 2716/4885FAAH 3136/4885PTGS1 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.