Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.50 |
| ▸ | FAAH | O00519 | 4/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8652814 | 0.98 | MGLL (0.47) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL12101786 | 0.96 | MGLL (0.46) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL145408 | 0.92 | KDM4E (0.46) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL3142849 | 0.88 | KDM4E (0.42) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL3142469 | 0.88 | MGLL (0.40) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL4639742 | 0.86 | MGLL (0.55) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL8121430 | 0.84 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL5450752 | 0.84 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL8115352 | 0.84 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2GAA | |
| SCHEMBL4578069 | 0.84 | MAPT (0.54) | MGLLFAAHPTGS1PTGS2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117858875-A | Hydroxy-and (halo) alkoxy-substituted tetrahydrofurans as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117794918-A | Substituted tetrahydrofuran analogues as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117794920-A | N- (hydroxyalkyl (hetero) aryl) tetrahydrofurancarboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117794919-A | N- (hydroxyalkyl (hetero) aryl) tetrahydrofurancarboxamide analogues as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-7173130-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-02-06 | — | — | US | disclosed |
| US-7118899-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-10-10 | — | — | US | disclosed |
| US-7115401-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-10-03 | — | — | US | disclosed |
| EP-0834074-B2 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | UNIV CALIFORNIA (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20040002123-A1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-01-01 | — | — | US | disclosed |
| US-6596522-B2 | Compositions and optical methods for determining transmembrane potentials across plasma membrane of biological cells | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-07-22 | — | — | US | disclosed |
| US-20020164577-A1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-11-07 | — | — | US | disclosed |
| US-20020137201-A1 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-09-26 | — | — | US | disclosed |
| US-6342379-B1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-01-29 | — | — | US | disclosed |
| US-6107066-A | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0834074-A1 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996041166-A2 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002123-A1 | Detection of transmembrane potentials by optical methods | TRPV1, TRPM2, MCU | MGLL 1219/4885FAAH 1435/4885PTGS1 3182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.