Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805789 | 0.92 | MAPT (0.31) | ITGB3ITGAVITGA2BKMT2ATHRB | |
| SCHEMBL6801812 | 0.86 | ALDH1A1 (0.33) | KMT2ATHRBMEN1MAPTHTR2C | |
| SCHEMBL4640112 | 0.81 | ITGB3 (0.51) | ITGB3ITGAVITGA2BKMT2ASTAT3 | |
| SCHEMBL4641339 | 0.81 | STAT3 (0.38) | ITGB3ITGAVKMT2ATHRBSTAT3 | |
| Benzene SCHEMBL6884463 | 0.78 | ITGB3 (0.40) | ITGB3ITGAVITGA2BKMT2ATHRB | |
| SCHEMBL6810268 | 0.78 | MAPT (0.32) | KMT2ATHRBMEN1MAPTHTR2C | |
| SCHEMBL6883915 | 0.77 | ITGB3 (0.43) | ITGB3ITGAVITGA2BKMT2ASTAT3 | |
| SCHEMBL6805791 | 0.77 | ITGB3 (0.44) | ITGB3ITGAVITGA2BKMT2AMAPT | |
| SCHEMBL4640085 | 0.76 | ITGAV (0.38) | ITGB3ITGAVITGA2BSTAT3MAPT | |
| SCHEMBL6876023 | 0.76 | SIRT2 (0.36) | KMT2ATHRBMEN1MAPTLIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |