Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 15/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 14/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641013 | 0.93 | ITGB3 (0.34) | ITGAVITGB3ITGA2BMAPTSTAT3 | |
| SCHEMBL4640251 | 0.88 | ITGB3 (0.49) | ITGAVITGB3ITGA2BITGB5 | |
| SCHEMBL4640112 | 0.86 | ITGB3 (0.51) | ITGAVITGB3ITGA2BMAPTITGB5 | |
| SCHEMBL6805470 | 0.85 | TDP1 (0.36) | ITGAVITGB3ITGA2BMAPT | |
| SCHEMBL4644035 | 0.85 | ITGB3 (0.44) | ITGAVITGB3ITGA2BMAPTITGB5 | |
| SCHEMBL7702988 | 0.85 | ITGB3 (0.44) | ITGAVITGB3ITGA2BMAPTITGB5 | |
| SCHEMBL6805959 | 0.84 | ITGB3 (0.40) | ITGAVITGB3ITGA2BMAPTITGB5 | |
| Benzene SCHEMBL6884463 | 0.84 | ITGB3 (0.40) | ITGAVITGB3ITGA2BMAPTSTAT3 | |
| SCHEMBL6876023 | 0.83 | SIRT2 (0.36) | MAPT | |
| SCHEMBL6806629 | 0.83 | TDP1 (0.35) | ITGAVITGB3ITGA2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |