SCHEMBL4640769

SCHEMBL4640769

CCOC(=O)Oc1ccc2c(c1)ncn2CCC(C)(C)N

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.44
KMT2A Q03164 4/20 0.42
GAA P10253 2/20 0.42
HPGD P15428 2/20 0.42
MTNR1A P48039 1/20 0.41
MTNR1B P49286 1/20 0.41
HDAC1 Q13547 2/20 0.40
F10 P00742 2/20 0.38
MAPT P10636 3/20 0.38
TNF P01375 1/20 0.38
POLB P06746 2/20 0.38
ALDH1A1 P00352 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HSD17B10 Q99714 2/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
KDM4E B2RXH2 1/20 0.37
HTT P42858 1/20 0.37
HDAC8 Q9BY41 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4640355 0.92 MTNR1A (0.49) CA2KMT2AGAAHPGDMTNR1A
SCHEMBL4775013 0.83 ALDH1A1 (0.38) CA2KMT2AHPGDMTNR1AMTNR1B
SCHEMBL4913399 0.82 NPC1 (0.47) KMT2AHPGDHDAC1F10MAPT
SCHEMBL4826368 0.80 ALDH1A1 (0.38) CA2KMT2AHPGDMTNR1AMTNR1B
SCHEMBL4641222 0.77 MTNR1A (0.45) CA2KMT2AHPGDMTNR1AMTNR1B
SCHEMBL4777107 0.77 TNF (0.36) CA2KMT2AGAAHPGDF10
SCHEMBL4916141 0.76 NPC1 (0.48) CA2KMT2AMTNR1AMTNR1BF10
SCHEMBL4638928 0.76 TRPM5 (0.35) CA2GAAF10MAPTTNF
SCHEMBL4889652 0.76 CNR2 (0.41) KMT2AHDAC1MAPTTNFPOLB
SCHEMBL3806522 0.74 HDAC1 (0.51) KMT2AGAAHPGDHDAC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1943229-A1 BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-07-16 EP disclosed
EP-1888612-A1 CRYSTALLINE SUGAR COMPOSITIONS AND METHOD OF MAKING Amicus Therapeutics, Inc. (US) 2008-02-20 EP disclosed
WO-2007048842-A1 BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-05-03 WO disclosed
WO-2006133447-A1 CRYSTALLINE SUGAR COMPOSITIONS AND METHOD OF MAKING AMICUS THERAPEUTICS, INC. (US) 2006-12-14 WO disclosed