Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807080 | 0.91 | ITGB3 (0.40) | ITGB3ITGAVDOT1LALDH1A1CYP1A2 | |
| SCHEMBL4641533 | 0.87 | ITGB3 (0.42) | SLC29A1SYKJAK2ITGB3ITGAV | |
| SCHEMBL6807305 | 0.83 | SYK (0.36) | SLC29A1SYKJAK2ADORA3ADORA2A | |
| SCHEMBL6016459 | 0.81 | HDAC6 (0.43) | SYKITGB3ITGAVCTSKCTSL | |
| SCHEMBL6016455 | 0.81 | HDAC6 (0.43) | SYKITGB3ITGAVCTSKCTSL | |
| SCHEMBL6807303 | 0.80 | JAK2 (0.36) | SLC29A1SYKJAK2ALDH1A1 | |
| SCHEMBL6807083 | 0.79 | CASP1 (0.37) | DOT1L | |
| SCHEMBL4640030 | 0.78 | TDP1 (0.45) | SYKADORA2AADORA1ITGB3ITGAV | |
| SCHEMBL6807059 | 0.78 | TDP1 (0.45) | SYKADORA2AADORA1ITGB3ITGAV | |
| SCHEMBL4641344 | 0.77 | ITGB3 (0.48) | ITGB3ITGAVMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |