Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGAV | P06756 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640085 | 0.93 | ITGAV (0.38) | ITGB3ITGAVITGA2BMAPTSTAT3 | |
| SCHEMBL7702988 | 0.90 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPT | |
| SCHEMBL4644035 | 0.90 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPT | |
| SCHEMBL6805791 | 0.89 | ITGB3 (0.44) | ITGB3ITGAVITGA2BMAPTSIRT2 | |
| SCHEMBL6876023 | 0.88 | SIRT2 (0.36) | MAPTSIRT2SIRT1SIRT3KMT2A | |
| Benzene SCHEMBL6882109 | 0.87 | MAPT (0.35) | ITGB3ITGAVITGA2BMAPTKMT2A | |
| SCHEMBL6882858 | 0.86 | CHKA (0.34) | ITGB3ITGAVITGA2BMAPTSIRT2 | |
| SCHEMBL6806629 | 0.86 | TDP1 (0.35) | ITGB3ITGAVITGA2BMAPTSIRT2 | |
| SCHEMBL6879623 | 0.85 | MAPT (0.34) | ITGB3ITGAVITGA2BMAPTSIRT2 | |
| SCHEMBL6881802 | 0.85 | ITGB3 (0.36) | ITGB3ITGAVITGA2BMAPTSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853084-B1 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AG (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |
| EP-0853084-A2 | Substituted purine derivatives as vitronectin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-15 | — | — | EP | disclosed |