Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805470 | 0.93 | TDP1 (0.36) | TDP1MAPTKMT2AMEN1THRB | |
| SCHEMBL6810562 | 0.90 | ITGB3 (0.41) | MAPTKMT2AMEN1ITGB3ITGAV | |
| SCHEMBL6805793 | 0.89 | ITGB3 (0.41) | TDP1MAPTKMT2AITGB3ITGAV | |
| SCHEMBL4641013 | 0.86 | ITGB3 (0.34) | MAPTKMT2AMEN1THRBSIRT2 | |
| SCHEMBL6805865 | 0.85 | TDP1 (0.41) | TDP1MAPTKMT2AMEN1THRB | |
| SCHEMBL4640085 | 0.83 | ITGAV (0.38) | MAPTITGB3ITGAVITGA2B | |
| SCHEMBL4640260 | 0.82 | ITGB3 (0.43) | MAPTKMT2AMEN1ITGB3ITGAV | |
| SCHEMBL6876023 | 0.80 | SIRT2 (0.36) | MAPTKMT2AMEN1THRBSIRT2 | |
| SCHEMBL6803682 | 0.80 | ITGB3 (0.45) | MAPTKMT2AMEN1THRBRXFP1 | |
| SCHEMBL6805973 | 0.77 | TDP1 (0.43) | TDP1MAPTKMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723727-B1 | VITRONECTIN RECEPTOR ANTAGONISTS; INHIBITORS OF BONE RESORPTION; OSTEOPOROSIS | HOECHST AKTIENGESELLSCHAFT (DE) | 2004-04-20 | — | — | US | disclosed |