Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TMPRSS15 | P98073 | 3/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647202 | 0.92 | CACNA1B (0.44) | MCHR1TMPRSS15CSNK1DCACNA1HCACNA1B | |
| SCHEMBL5247640 | 0.91 | MCHR1 (0.54) | MCHR1CHRM2ADRA2ACHRM1ADRA2B | |
| SCHEMBL4641406 | 0.91 | MAPT (0.42) | MCHR1TMPRSS15CTSD | |
| SCHEMBL4643663 | 0.90 | ALDH1A1 (0.46) | MCHR1TMPRSS15 | |
| SCHEMBL4643578 | 0.90 | MCHR1 (0.44) | MCHR1HTR2CTMPRSS15 | |
| SCHEMBL4641593 | 0.89 | MAPT (0.46) | MCHR1TMPRSS15 | |
| SCHEMBL4643026 | 0.87 | MCHR1 (0.42) | MCHR1TMPRSS15 | |
| SCHEMBL4643038 | 0.85 | MCHR1 (0.48) | MCHR1HTR2CTMPRSS15 | |
| SCHEMBL4645813 | 0.84 | TMPRSS15 (0.41) | MCHR1TMPRSS15 | |
| SCHEMBL4641355 | 0.83 | ALDH1A1 (0.44) | TMPRSS15CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |