Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641377 | 0.92 | MCHR1 (0.45) | CACNA1BCACNA1HMCHR1ADRA1DADRA1A | |
| SCHEMBL4643663 | 0.91 | ALDH1A1 (0.46) | MCHR1TMPRSS15ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4643578 | 0.90 | MCHR1 (0.44) | MCHR1TMPRSS15ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4641593 | 0.90 | MAPT (0.46) | MCHR1TMPRSS15ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4641406 | 0.90 | MAPT (0.42) | MCHR1TMPRSS15ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5246435 | 0.89 | MCHR1 (0.54) | CACNA1BCACNA1HMCHR1ADRA1DADRA1A | |
| SCHEMBL4643026 | 0.88 | MCHR1 (0.42) | MCHR1TMPRSS15SMN1; SMN2MEN1LMNA | |
| SCHEMBL4643038 | 0.85 | MCHR1 (0.48) | MCHR1TMPRSS15ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4645813 | 0.85 | TMPRSS15 (0.41) | MCHR1TMPRSS15ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4641355 | 0.84 | ALDH1A1 (0.44) | CACNA1BTMPRSS15ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |