Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PER2 | O15055 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4644618 | 0.81 | NOTUM (0.46) | LMNAMEN1MAPTKMT2ANOTUM | |
| SCHEMBL18593390 | 0.80 | NOTUM (0.45) | NOTUMPER2GAA | |
| SCHEMBL4644950 | 0.78 | HTR7 (0.48) | MEN1KMT2ANOTUMMGLLGAA | |
| SCHEMBL4739954 | 0.78 | FAAH (0.46) | NOTUMMGLLPER2 | |
| SCHEMBL609915 | 0.75 | NOTUM (0.42) | MEN1MAPTKMT2ANOTUMTSHR | |
| SCHEMBL29526585 | 0.75 | ALDH1A1 (0.48) | LMNAMAPTKMT2ANOTUM | |
| SCHEMBL16480455 | 0.74 | PARP1 (0.41) | MEN1KMT2ANOTUMCHRM4DRD2 | |
| SCHEMBL4644173 | 0.73 | ALDH1A1 (0.43) | MEN1KMT2AMGLLPARP1 | |
| SCHEMBL16480456 | 0.69 | CD274 (0.45) | MAPTCASP1CASP7GAA | |
| SCHEMBL11513544 | 0.68 | ALOX5 (0.50) | LMNAMEN1MAPTKMT2AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110294701-B | Synthetic method of 5-methyl-2-pyrrolidone or derivatives thereof | 厦门大学 | 2021-07-09 | — | — | CN | disclosed |
| CN-110294701-A | A kind of synthetic method of 5- N-methyl-2-2-pyrrolidone N or derivatives thereof | 厦门大学 | 2019-10-01 | — | — | CN | disclosed |
| EP-1605756-A4 | PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE BY REDUCTIVE AMINATION OF LEVULINIC ACID ESTERS WITH ARYL AND ALKYL AMINES | DU PONT (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7129362-B2 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2006-10-31 | — | — | US | disclosed |
| CN-1764379-A | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone | DU PONT (US) | 2006-04-26 | — | — | CN | disclosed |
| EP-1605756-A2 | PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE BY REDUCTIVE AMINATION OF LEVULINIC ACID ESTERS WITH ARYL AND ALKYL AMINES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20050137406-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | E. I. DU PONT DE NEMOURS AND COMPANY | 2005-06-23 | — | — | US | disclosed |
| US-20050038265-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | MANZER LEO ERNEST (US) | 2005-02-17 | — | — | US | disclosed |
| US-20050033062-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | MANZER LEO ERNEST (US) | 2005-02-10 | — | — | US | disclosed |
| US-20050033063-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | MANZER LEO ERNEST (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004085348-A2 | PRODUCTION OF 5-METHYL-N-ARYL-2-PYRROLIDONE AND 5-METHYL-N-ALKYL-2-PYRROLIDONE | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2004-10-07 | — | — | WO | disclosed |
| US-20040192938-A1 | Production of 5-mehyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033063-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | LMNA 2302/4885MEN1 2826/4885MAPT 2001/4885 |
| US-20050137406-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | LMNA 2835/4885MEN1 2949/4885MAPT 1803/4885 |
| US-20040192938-A1 | Production of 5-mehyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines | PAH, ALDH18A1, PNPO | LMNA 2473/4885MEN1 1674/4885MAPT 1747/4885 |
| US-20050038265-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | LMNA 2302/4885MEN1 2826/4885MAPT 2001/4885 |
| US-20050033062-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with aryl and alkyl amines | ALDH18A1, PNPO, ABAT | LMNA 2302/4885MEN1 2826/4885MAPT 2001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.