Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 13/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641201 | 0.93 | AGPAT2 (0.42) | AGPAT2MAPTTHRBPOLB | |
| SCHEMBL4643098 | 0.92 | MAPT (0.46) | AGPAT2MAPTTP53POLB | |
| SCHEMBL4641410 | 0.91 | AGPAT2 (0.42) | AGPAT2MAPTTHRBPOLB | |
| SCHEMBL5247614 | 0.88 | MAPT (0.49) | AGPAT2MAPTTP53THRBPOLB | |
| SCHEMBL4641300 | 0.86 | AGPAT2 (0.42) | AGPAT2MAPTTP53THRBPOLB | |
| SCHEMBL4641368 | 0.86 | PTGDR2 (0.40) | MAPTTP53THRBPOLB | |
| SCHEMBL4646624 | 0.86 | MAPT (0.42) | MAPTTP53THRB | |
| SCHEMBL4642981 | 0.81 | NPC1 (0.38) | AGPAT2MAPTTP53THRBPOLB | |
| SCHEMBL13054298 | 0.81 | MAPT (0.49) | MAPTTP53THRBPOLB | |
| SCHEMBL4641167 | 0.81 | AGPAT2 (0.46) | AGPAT2MAPTTP53THRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |