Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTR1F | P30939 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643098 | 0.93 | MAPT (0.46) | PTGDR2MAPTPOLBHTR1FTP53 | |
| SCHEMBL4646624 | 0.92 | MAPT (0.42) | PTGDR2MAPTHTR1FTP53MCHR1 | |
| SCHEMBL13054171 | 0.88 | MAPT (0.49) | PTGDR2MAPTPOLBHTR1FTP53 | |
| SCHEMBL4641201 | 0.87 | AGPAT2 (0.42) | PTGDR2MAPTPOLBTHRB | |
| SCHEMBL4643502 | 0.87 | PTGDR2 (0.40) | PTGDR2MAPTPOLBHTR1FMCHR1 | |
| SCHEMBL4641300 | 0.86 | AGPAT2 (0.42) | MAPTPOLBTP53MCHR1THRB | |
| SCHEMBL4643048 | 0.86 | AGPAT2 (0.42) | MAPTPOLBTP53THRB | |
| SCHEMBL4641410 | 0.86 | AGPAT2 (0.42) | PTGDR2MAPTPOLBMCHR1THRB | |
| SCHEMBL4643115 | 0.83 | PTGDR2 (0.43) | PTGDR2MAPTPOLBTP53THRB | |
| SCHEMBL4641252 | 0.82 | PTGDR2 (0.39) | PTGDR2MAPTHTR1FTP53MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |