Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTR1F | P30939 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 10/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641368 | 0.93 | PTGDR2 (0.40) | MAPTPOLBTP53HTR1FPTGDR2 | |
| SCHEMBL4641201 | 0.92 | AGPAT2 (0.42) | MAPTPOLBPTGDR2KDM4ENPC1 | |
| SCHEMBL4643048 | 0.92 | AGPAT2 (0.42) | MAPTPOLBTP53AGPAT2 | |
| SCHEMBL4646624 | 0.92 | MAPT (0.42) | MAPTTP53HTR1FPTGDR2KDM4E | |
| SCHEMBL4641410 | 0.89 | AGPAT2 (0.42) | MAPTPOLBPTGDR2KDM4ENPC1 | |
| SCHEMBL5244647 | 0.89 | MAPT (0.54) | MAPTPOLBTP53HTR1FPTGDR2 | |
| SCHEMBL4641300 | 0.86 | AGPAT2 (0.42) | MAPTPOLBTP53KDM4ENPC1 | |
| SCHEMBL4643115 | 0.82 | PTGDR2 (0.43) | MAPTPOLBTP53PTGDR2KDM4E | |
| SCHEMBL4641252 | 0.82 | PTGDR2 (0.39) | MAPTTP53HTR1FPTGDR2KDM4E | |
| SCHEMBL13054171 | 0.82 | MAPT (0.49) | MAPTPOLBTP53HTR1FPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |