Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244477 | 0.89 | MAPT (0.47) | MAPTKDRRXFP1THRB | |
| SCHEMBL4643537 | 0.87 | MAPT (0.42) | CHRM3MAPTRXFP1THRBCETP | |
| SCHEMBL4641201 | 0.87 | AGPAT2 (0.42) | AGPAT2MAPTKDRCASP3SENP8 | |
| SCHEMBL4643855 | 0.83 | AGPAT2 (0.45) | AGPAT2MAPTKDRCASP3SENP8 | |
| SCHEMBL4641410 | 0.81 | AGPAT2 (0.42) | AGPAT2MAPTKDRCASP3SENP8 | |
| SCHEMBL4643048 | 0.80 | AGPAT2 (0.42) | AGPAT2MAPTTHRB | |
| SCHEMBL4643098 | 0.79 | MAPT (0.46) | AGPAT2MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4641336 | 0.78 | AGPAT2 (0.46) | AGPAT2MAPTKDRCASP3SENP8 | |
| SCHEMBL4643630 | 0.77 | MAPT (0.41) | MAPTRXFP1THRBCETPSMN1; SMN2 | |
| SCHEMBL4641167 | 0.76 | AGPAT2 (0.46) | AGPAT2MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |