SCHEMBL4643573

SCHEMBL4643573

CC[CH]C(=O)O[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
HSD11B1 P28845 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP2C19 P33261 2/20 0.32
HIF1A Q16665 1/20 0.32
ABL1 P00519 1/20 0.31
PIN1 Q13526 2/20 0.31
MDM4 O15151 1/20 0.31
LMNA P02545 1/20 0.31
MDM2 Q00987 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4647013 0.88 MAPT (0.36) MAPTHSD11B1MEN1KMT2ACYP2C19
SCHEMBL5973442 0.83 HCAR2 (0.37) MAPTHSD11B1MEN1KMT2AMDM4
SCHEMBL5974325 0.83 HCAR2 (0.37) MAPTHSD11B1MEN1KMT2AMDM4
SCHEMBL5973451 0.83 HCAR2 (0.37) MAPTHSD11B1MEN1KMT2AMDM4
SCHEMBL4647510 0.82 MAPT (0.37) MAPTHSD11B1MEN1KMT2ACYP2C19
SCHEMBL2189980 0.81 THRB (0.38) MAPTKMT2ACYP2C19
SCHEMBL4643712 0.80 MAPT (0.38) MAPTMEN1KMT2APIN1LMNA
SCHEMBL28219395 0.79 HCAR2 (0.44) MAPTLMNA
SCHEMBL9845210 0.79 ELANE (0.39) MAPTMEN1KMT2ACYP2C19HIF1A
SCHEMBL560289 0.78 HCAR2 (0.41) MAPTMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed