Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | OGA | O60502 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081688 | 0.81 | MAPK14 (0.44) | HTR7HTR2CHDAC3HDAC1HDAC2 | |
| SCHEMBL4644151 | 0.73 | RAB9A (0.45) | HTR7ADRA2BADRA2CSLC6A2HRH2 | |
| SCHEMBL6027180 | 0.72 | P2RX7 (0.51) | HTR2ARAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL12233647 | 0.70 | CYP4F2 (0.41) | RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL3427156 | 0.69 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNA | |
| SCHEMBL6027092 | 0.68 | P2RX7 (0.46) | HTR2ARAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL30807261 | 0.68 | SMN1; SMN2 (0.57) | HTR2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30938203 | 0.67 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4ELMNA | |
| SCHEMBL19438891 | 0.67 | CHRNB2 (0.57) | SIGMAR1RAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL9185281 | 0.67 | IDO1 (0.42) | RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675830-A4 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1675830-A2 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005033072-A2 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC. (US) | 2005-04-14 | — | — | WO | disclosed |