Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730411 | 0.88 | GRM6 (0.49) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL2718238 | 0.81 | CA12 (0.48) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL10982569 | 0.80 | GRM6 (0.43) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL6830109 | 0.80 | POLB (0.45) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL976497 | 0.79 | MMP2 (0.47) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL3586373 | 0.79 | CA12 (0.38) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL27651123 | 0.78 | GRM6 (0.42) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL31461653 | 0.77 | THRB (0.43) | ALDH1A1KDM4EMAPTTHRBHSD17B10 | |
| SCHEMBL31020766 | 0.76 | GRM6 (0.41) | GRM6ALDH1A1HPGDKDM4EGLA | |
| SCHEMBL27770533 | 0.76 | GRM6 (0.41) | GRM6ALDH1A1HPGDKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288398-B2 | Antiproliferative pyrimidyl, fused pyrimidyl and pyrimidyl hydrazones | MERCK SERONO SA (CH) | 2012-10-16 | — | — | US | disclosed |
| US-20120238575-A1 | ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| US-20080287474-A1 | Antiproliferative Pyrimidyl, Fused Pyrimidyl and Pyrimidyl Hydrazones | LABORATOIRES SERONO SA (CH) | 2008-11-20 | — | — | US | disclosed |
| EP-1963321-A2 | DIBENZONAPHTHYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1957469-A1 | ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES | Laboratoires Serono SA (CH) | 2008-08-20 | — | — | EP | disclosed |
| US-7388016-B2 | Dibenzonaphthyridine derivatives and methods of use thereof | WYETH (US) | 2008-06-17 | — | — | US | disclosed |
| WO-2007070319-A2 | DIBENZONAPHTHYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | WYETH (US) | 2007-06-21 | — | — | WO | disclosed |
| US-20070135429-A1 | Dibenzonaphthyridine derivatives and methods of use thereof | WYETH (US) | 2007-06-14 | — | — | US | disclosed |
| WO-2007065940-A1 | ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES | LABORATOIRES SERONO S.A. (CH) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287474-A1 | Antiproliferative Pyrimidyl, Fused Pyrimidyl and Pyrimidyl Hydrazones | TYMP, DHFR, DPYD | GRM6 3883/4885ALDH1A1 120/4885HPGD 353/4885 |
| US-20120238575-A1 | ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES | TYMP, DHFR, DPYD | GRM6 3883/4885ALDH1A1 120/4885HPGD 353/4885 |
| US-20070135429-A1 | Dibenzonaphthyridine derivatives and methods of use thereof | FANCD2, DDT, BRCA1 | GRM6 4658/4885ALDH1A1 946/4885HPGD 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.