Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646542 | 0.93 | MCHR1 (0.41) | MCHR1MAPTHDAC1HDAC2PTGS2 | |
| SCHEMBL4642981 | 0.93 | NPC1 (0.38) | MCHR1MAPTHDAC1HDAC2PTGS2 | |
| SCHEMBL4641252 | 0.92 | PTGDR2 (0.39) | MCHR1MAPTTP53PTGDR2THRB | |
| SCHEMBL4643611 | 0.92 | SMN1; SMN2 (0.39) | MCHR1MAPTKDRAGPAT2TP53 | |
| SCHEMBL4641302 | 0.92 | MAPT (0.42) | MCHR1MAPTKDRPTGS2TP53 | |
| SCHEMBL4641260 | 0.91 | MCHR1 (0.38) | MCHR1KDRHDAC1HDAC2PTGDR2 | |
| SCHEMBL4641270 | 0.88 | MAPT (0.40) | MCHR1MAPTHDAC1HDAC2TP53 | |
| SCHEMBL4643502 | 0.84 | PTGDR2 (0.40) | MCHR1MAPTPTGDR2 | |
| SCHEMBL4641201 | 0.83 | AGPAT2 (0.42) | CASP3SENP8SENP7SENP6MAPT | |
| SCHEMBL4641410 | 0.82 | AGPAT2 (0.42) | CASP3SENP8SENP7SENP6MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |