Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4642981 | 0.92 | NPC1 (0.38) | MAPTTHRBRAB9AMCHR1PTGS2 | |
| SCHEMBL4644568 | 0.92 | CASP3 (0.39) | MAPTTHRBMCHR1PTGS2RXFP1 | |
| SCHEMBL4641252 | 0.92 | PTGDR2 (0.39) | MAPTTHRBRAB9AMCHR1SMN1; SMN2 | |
| SCHEMBL4643611 | 0.92 | SMN1; SMN2 (0.39) | MAPTRAB9ALMNAMCHR1TSHR | |
| SCHEMBL4641260 | 0.89 | MCHR1 (0.38) | RAB9AMCHR1NPC1KDRKDM4E | |
| SCHEMBL4646542 | 0.88 | MCHR1 (0.41) | MAPTTHRBLMNAMCHR1PTGS2 | |
| SCHEMBL4641270 | 0.87 | MAPT (0.40) | MAPTRAB9ALMNAMCHR1TSHR | |
| SCHEMBL4643502 | 0.84 | PTGDR2 (0.40) | MAPTMCHR1POLBPTGDR2 | |
| SCHEMBL4641300 | 0.83 | AGPAT2 (0.42) | MAPTTHRBRAB9AMCHR1TSHR | |
| SCHEMBL4646624 | 0.83 | MAPT (0.42) | MAPTTHRBRAB9AMCHR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |