Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1F | P30939 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4642981 | 0.93 | NPC1 (0.38) | PTGDR2MCHR1MAPTKDM4EALDH1A1 | |
| SCHEMBL4641260 | 0.92 | MCHR1 (0.38) | PTGDR2MCHR1KDM4EALDH1A1RAB9A | |
| SCHEMBL4644568 | 0.92 | CASP3 (0.39) | PTGDR2MCHR1MAPTTP53THRB | |
| SCHEMBL4643611 | 0.92 | SMN1; SMN2 (0.39) | PTGDR2MCHR1MAPTKDM4EALDH1A1 | |
| SCHEMBL4641302 | 0.92 | MAPT (0.42) | PTGDR2MCHR1MAPTKDM4EALDH1A1 | |
| SCHEMBL4643502 | 0.90 | PTGDR2 (0.40) | PTGDR2MCHR1MAPTHTR1AHTR1F | |
| SCHEMBL4646542 | 0.89 | MCHR1 (0.41) | PTGDR2MCHR1MAPTKDM4EHPGD | |
| SCHEMBL4641270 | 0.88 | MAPT (0.40) | MCHR1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4646624 | 0.88 | MAPT (0.42) | PTGDR2MCHR1MAPTKDM4EALDH1A1 | |
| SCHEMBL5247593 | 0.88 | ESRRG (0.44) | PTGDR2MCHR1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |