Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4644568 | 0.93 | CASP3 (0.39) | MCHR1MAPTTP53THRBHDAC1 | |
| SCHEMBL4643611 | 0.93 | SMN1; SMN2 (0.39) | MCHR1MAPTTP53LMNAAGPAT2 | |
| SCHEMBL4642981 | 0.89 | NPC1 (0.38) | MCHR1MAPTTP53THRBHDAC1 | |
| SCHEMBL4641260 | 0.89 | MCHR1 (0.38) | MCHR1HDAC1HDAC2CHRM3MEN1 | |
| SCHEMBL4641252 | 0.89 | PTGDR2 (0.39) | MCHR1MAPTTP53THRBKDM4E | |
| SCHEMBL4641302 | 0.88 | MAPT (0.42) | MCHR1MAPTTP53THRBLMNA | |
| SCHEMBL4641270 | 0.86 | MAPT (0.40) | MCHR1MAPTTP53LMNAHDAC1 | |
| SCHEMBL4643502 | 0.82 | PTGDR2 (0.40) | MCHR1MAPTCHRM3PTGDR2 | |
| SCHEMBL4641300 | 0.81 | AGPAT2 (0.42) | MCHR1MAPTTP53THRBAGPAT2 | |
| SCHEMBL4641201 | 0.80 | AGPAT2 (0.42) | MAPTTHRBTDP1AGPAT2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |