SCHEMBL464495

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL31490054	0.95	HTT (0.54)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL6840857	0.91	SMN1; SMN2 (0.52)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL16558066	0.89	HTT (0.50)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL7156418	0.89	SMN1; SMN2 (0.52)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL7511729	0.86	MAPT (0.53)	TGM2MAPTHTTFOLH1KLK7
	SCHEMBL6229809	0.85	MAPT (0.52)	MAPTHTTFOLH1KLK7KLK5
	SCHEMBL16789588	0.85	HTT (0.58)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL3052852	0.85	HTT (0.61)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL9667908	0.85	HTT (0.61)	TGM2MAPTHTTKEAP1NFE2L2
	SCHEMBL25787604	0.85	HTT (0.61)	TGM2MAPTHTTKEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.