⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24868147 | 1.00 | — | — | |
| SCHEMBL24868385 | 0.76 | — | — | |
| SCHEMBL30309362 | 0.76 | — | — | |
| SCHEMBL3549256 | 0.76 | APLNR (0.32) | — | |
| SCHEMBL19240422 | 0.76 | MITF (0.31) | — | |
| SCHEMBL16865200 | 0.74 | HSD11B1 (0.39) | — | |
| SCHEMBL10857833 | 0.74 | APLNR (0.31) | — | |
| SCHEMBL3958437 | 0.73 | GRM2 (0.32) | — | |
| SCHEMBL3958433 | 0.73 | GRM2 (0.32) | — | |
| SCHEMBL16865154 | 0.73 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748043-B1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2008-08-20 | — | — | EP | disclosed |
| US-7348344-B2 | Polysubstituted 1,1-pyridyloxycyclopropanamine compounds | LES LABORATOIRES SERVIER (FR) | 2008-03-25 | — | — | US | disclosed |
| EP-1748043-A1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2007-01-31 | — | — | EP | disclosed |