Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958437 | 0.81 | GRM2 (0.32) | HSD11B1GRM2GRM5GRM1 | |
| SCHEMBL3958433 | 0.81 | GRM2 (0.32) | HSD11B1GRM2GRM5GRM1 | |
| SCHEMBL10990279 | 0.77 | ALDH1A1 (0.35) | — | |
| SCHEMBL24868147 | 0.76 | — | — | |
| SCHEMBL4645147 | 0.76 | — | — | |
| SCHEMBL6607890 | 0.73 | PDE4A (0.34) | — | |
| SCHEMBL11125888 | 0.72 | ABCC4 (0.32) | — | |
| SCHEMBL30309362 | 0.71 | — | — | |
| SCHEMBL24868385 | 0.71 | — | — | |
| SCHEMBL669391 | 0.71 | MAPT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146043-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | CYCLACEL PHARMACEUTICALS INC. (US) | 2026-05-28 | — | — | US | disclosed |
| US-12570660-B2 | Process for the preparation of a pyrimidino-diazepine derivative | CYCLACEL PHARMACEUTICALS, INC (GB) | 2026-03-10 | — | — | US | disclosed |
| US-12534466-B2 | Crystalline forms of pyrimidino diazepine derivative | CYCLACEL PHARMACEUTICALS INC. (US) | 2026-01-27 | — | — | US | disclosed |
| US-20220289755-A1 | PROCESS FOR THE PREPARATION OF A PYRIMIDINO-DIAZEPINE DERIVATIVE | TETHRA BIOSCIENCES INC. | 2022-09-15 | — | — | US | disclosed |
| US-20220281880-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | TETHRA BIOSCIENCES INC. | 2022-09-08 | — | — | US | disclosed |
| EP-4013503-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | Cyclacel Limited (GB) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021032959-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | CYCLACEL LIMITED (GB) | 2021-02-25 | — | — | WO | disclosed |
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12570660-B2 | Process for the preparation of a pyrimidino-diazepine derivative | AZI2, TFPI, GTF2I | APLNR 4717/4885HSD11B1 1551/4885GRM2 669/4885 |
| US-20260146043-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | CTNND1, CCNC, SFN | APLNR 4715/4885HSD11B1 569/4885GRM2 1789/4885 |
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | APLNR 2009/4885HSD11B1 83/4885GRM2 3597/4885 |
| US-12534466-B2 | Crystalline forms of pyrimidino diazepine derivative | PLK1, BUB1, CDC25C | APLNR 4704/4885HSD11B1 2708/4885GRM2 3669/4885 |
| US-20220281880-A1 | CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE | PDCD5, NLRP3, PDCD1 | APLNR 4727/4885HSD11B1 1637/4885GRM2 1806/4885 |
| US-20220289755-A1 | PROCESS FOR THE PREPARATION OF A PYRIMIDINO-DIAZEPINE DERIVATIVE | DHPS, CYP3A5, AZI2 | APLNR 4608/4885HSD11B1 356/4885GRM2 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.