SCHEMBL464524

SCHEMBL464524

CCCCCCCCCCCCCCN(CCCCCCCCCCCC)C(=O)C(CN)NC(=O)OC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSK P43235 10/20 0.46
CTSS P25774 3/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL464525 0.88 CTSK (0.48) CTSKCTSS
SCHEMBL8143993 0.88 CTSK (0.48) CTSKCTSS
SCHEMBL9439085 0.86 CTSK (0.58) CTSKCTSS
SCHEMBL7256814 0.84 CCKBR (0.53)
SCHEMBL9538440 0.82 CTSK (0.54) CTSKCTSS
SCHEMBL31549494 0.82 CTSK (0.48) CTSKCTSS
SCHEMBL17265668 0.82 CTSK (0.48) CTSKCTSS
SCHEMBL9439347 0.81 CTSK (0.52) CTSKCTSS
SCHEMBL15743644 0.81 CTSK (0.44) CTSKCTSS
SCHEMBL8176790 0.80 CCKBR (0.47) CTSKCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170036990-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2017-02-09 US disclosed
US-20150359906-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2015-12-17 US disclosed
US-9125820-B2 Lipids, lipid complexes and use thereof SILENCE THERAPEUTICS GMBH (DE) 2015-09-08 US disclosed
US-20140329885-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS GMBH (DE) 2014-11-06 US disclosed
US-20130165381-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2013-06-27 US disclosed
US-20120065138-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2012-03-15 US disclosed
US-20110294871-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF SILENCE THERAPEUTICS AG (DE) 2011-12-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065138-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, SGMS1 CTSK 2810/4885CTSS 2754/4885
US-20110294871-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, SGMS1 CTSK 2810/4885CTSS 2754/4885
US-20130165381-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC CTSK 2191/4885CTSS 2384/4885
US-20170036990-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC CTSK 2191/4885CTSS 2384/4885
US-20150359906-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC CTSK 2191/4885CTSS 2384/4885
US-20140329885-A1 LIPIDS, LIPID COMPLEXES AND USE THEREOF MGLL, LIPA, LIPC CTSK 2191/4885CTSS 2384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.