SCHEMBL6612453

SCHEMBL6612453

O=C(O)c1cc(Cc2ccccn2)[nH]c(=O)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
IDO1 P14902 1/20 0.42
KDM4C Q9H3R0 4/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
PIN1 Q13526 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
KDM4E B2RXH2 3/20 0.40
KDM4A O75164 2/20 0.40
PTPRA P18433 1/20 0.40
KDM6B O15054 1/20 0.40
KDM5C P41229 1/20 0.40
KDM2A Q9Y2K7 1/20 0.40
KDM3A Q9Y4C1 1/20 0.40
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39
TSHR P16473 1/20 0.39
KDM5A P29375 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6613866 0.79 SMN1; SMN2 (0.57) KDM4CSMN1; SMN2KDM4AMEN1KMT2A
SCHEMBL14123147 0.78 ALDH1A1 (0.58) HRH4HRH3SMN1; SMN2KDM4EALDH1A1
SCHEMBL14123256 0.75 SMN1; SMN2 (0.60) HRH4HRH3SMN1; SMN2CYP2C19KDM4E
SCHEMBL14603855 0.73 KDM4A (0.50) KDM4CSMN1; SMN2KDM4EKDM4AMEN1
SCHEMBL14252431 0.72 KDM4C (0.50) KDM4CSMN1; SMN2PIN1KDM4EKDM4A
SCHEMBL14966592 0.72 GPR84 (0.67) KDM5AKDM5B
SCHEMBL4649823 0.71 KDM4E (0.45) HRH4HRH3KDM4CSMN1; SMN2CYP1A2
SCHEMBL18906068 0.71 L3MBTL1 (0.57) KDM4CSMN1; SMN2CYP1A2CYP2C19KDM4E
SCHEMBL18906030 0.71 FOLH1 (0.51) KDM4CSMN1; SMN2CYP1A2CYP2C19KDM4E
SCHEMBL28849291 0.70 KEAP1 (0.46) KDM4CSMN1; SMN2CYP1A2CYP2C19KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1448196-A1 BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. Hoffmann-La Roche AG (CH) 2004-08-25 EP claimed
WO-2003043634-A1 BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2003-05-30 WO claimed
EP-1448196-A1 BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. Hoffmann-La Roche AG (CH) 2004-08-25 EP disclosed
WO-2003043634-A1 BENZOTHIAZOLE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2003-05-30 WO disclosed