Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL5373299 | 0.91 | ALDH1A1 (0.46) | ALDH1A1TRPA1FFAR3OR51E2LMNA | |
| Acetic Acid SCHEMBL6419060 | 0.91 | ALDH1A1 (0.46) | ALDH1A1TRPA1FFAR3OR51E2LMNA | |
| SCHEMBL50253 | 0.87 | — | — | |
| Urea SCHEMBL8051050 | 0.85 | ALDH1A1 (0.46) | ALDH1A1TRPA1OR51E2LMNACA2 | |
| Benzene SCHEMBL11077172 | 0.84 | TRPA1 (0.52) | ALDH1A1TRPA1LMNAADRA1ATDP1 | |
| Bicarbonate SCHEMBL8018733 | 0.84 | ALDH1A1 (0.58) | ALDH1A1TRPA1LMNACA2ADRA1A | |
| Bicarbonate SCHEMBL13372638 | 0.83 | FFAR3 (0.44) | ALDH1A1FFAR3CA2ADRA1ATDP1 | |
| Ammonia Solution, Strong SCHEMBL11672040 | 0.83 | — | — | |
| Methacrylic Acid SCHEMBL4158756 | 0.82 | TGFBR1 (0.41) | ALDH1A1TRPA1LMNATDP1 | |
| Acrylic Acid SCHEMBL9347976 | 0.82 | LMNA (0.48) | ALDH1A1TRPA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1965897-A1 | APPARATUS AND PROCESS FOR FORMING AN ADHESIVE AND/OR SEALANT COMPOSITION, ADHESIVE AND/OR SEALANT COMPOSITION PRODUCED IN THIS WAY AND ADHESIVE-BONDED SUBSTRATES | Sika Technology AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007074139-A1 | APPARATUS AND PROCESS FOR FORMING AN ADHESIVE AND/OR SEALANT COMPOSITION, ADHESIVE AND/OR SEALANT COMPOSITION PRODUCED IN THIS WAY AND ADHESIVE-BONDED SUBSTRATES | SIKA TECHNOLOGY AG (CH) | 2007-07-05 | — | — | WO | disclosed |
| EP-1800738-A1 | Device and method for producing an adhesive and/or sealant composition, adhesive and/or sealant composition thus produced, and bonded substrates | Sika Technology AG (CH) | 2007-06-27 | — | — | EP | disclosed |
| EP-1728840-A1 | Method for application and adhesion | Sika Technology AG (CH) | 2006-12-06 | — | — | EP | disclosed |
| EP-1728807-A1 | Two-component hot melt adhesive containing water | Sika Technology AG (CH) | 2006-12-06 | — | — | EP | disclosed |