SCHEMBL4652203

SCHEMBL4652203

CC1=Cc2c(Br)cc(-c3ccncc3)cc2C1C(C)C1C(C)=Cc2c(Br)cc(-c3ccncc3)cc21

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4652045 0.86 CRHBP (0.39)
SCHEMBL1453062 0.81 KIF11 (0.33) LMNAMAPT
SCHEMBL1453419 0.79 LMNA (0.31) LMNAMAPT
SCHEMBL1453561 0.79 LMNA (0.31) LMNAMAPT
SCHEMBL1452921 0.79 LMNA (0.31) LMNAMAPT
SCHEMBL4653367 0.78 KCNH2 (0.32) LMNAMAPT
SCHEMBL4708515 0.76 CYP3A4 (0.31)
SCHEMBL4651165 0.76
SCHEMBL4652089 0.75 QDPR (0.35) LMNAMAPT
SCHEMBL4650927 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1971621-A1 PREPARATION OF SUBSTITUTED BRIDGED INDENYL AND RELATED LIGANDS ExxonMobil Chemical Patents Inc. (US) 2008-09-24 EP disclosed
WO-2007070045-A1 PREPARATION OF SUBSTITUTED BRIDGED INDENYL AND RELATED LIGANDS EXXONMOBIL CHEMICAL PATENTS, INC. (US) 2007-06-21 WO disclosed