Sugi Predict

Sugi Predict / Compounds / SCHEMBL4654498

SCHEMBL4654498

SCHEMBL4654498

O=C(c1cccc2c1[nH]c1ccccc12)c1cccc2c1[nH]c1ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PBRM1 Q86U86 2/20 0.60
▸ KIF11 P52732 4/20 0.53
▸ PIM3 Q86V86 2/20 0.51
▸ PIM1 P11309 1/20 0.51
▸ JAK2 O60674 1/20 0.51
▸ TP53 P04637 1/20 0.51
▸ MAPT P10636 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ KLK7 P49862 1/20 0.51
▸ PARP14 Q460N5 5/20 0.49
▸ GPR84 Q9NQS5 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ GPR3 P46089 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ MPL P40238 1/20 0.48
▸ GABRP O00591 1/20 0.47
▸ GABRD O14764 1/20 0.47
▸ GABRA1 P14867 1/20 0.47
▸ GABRB1 P18505 1/20 0.47
▸ GABRG2 P18507 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6887279 0.98 PBRM1 (0.58) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL11801609 0.92 PBRM1 (0.65) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL6887283 0.91 PBRM1 (0.55) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL22371699 0.90 KIF11 (0.62) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL30480324 0.90 KIF11 (0.62) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL3910030 0.90 PBRM1 (0.58) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL31485136 0.90 PBRM1 (0.58) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL1515615 0.90 PBRM1 (0.54) PBRM1KIF11PIM3PIM1JAK2
SCHEMBL21763820 0.89 GPR84 (0.70) PBRM1PIM3PIM1TP53GPR84
SCHEMBL27623354 0.88 PBRM1 (0.53) PBRM1KIF11PIM3PIM1JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114395112-B Hydrophobic block-containing polycarbazole anion exchange membrane and preparation method thereof 北京化工大学 2023-01-24 — — CN claimed
CN-102924366-A Carbazole ketone intermediate containing multi-functional group structure and preparation method for carbazole ketone intermediate CHANGCHUN APPLIED CHEMISTRY 2013-02-13 — — CN claimed
EP-1432388-B1 AGENT FOR COLOURING FIBRES CONTAINING KERATIN HENKEL AG & CO KGAA (DE) 2008-06-18 — — EP claimed
EP-1432428-B1 Agent for colouring fibres containing keratin HENKEL KGAA (DE) 2006-11-02 — — EP claimed
US-20050262647-A1 Agent for dyeing fibers containing keratin HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 2005-12-01 — — US claimed
CN-1045438-C 4H carbazoleone Mannich base and its synthesizing method and application SHANGHAI INST ORGANIC CHEM (CN) 1999-10-06 — — CN claimed
CN-1145902-A Preparation of carbazones compounds SHANGHAI HUALIAN PHARMACEUTICA (CN) 1997-03-26 — — CN claimed
CN-1113239-A 4H carbazoleone Mannich base and its synthesizing method and application SHANGHAI INST ORGANIC CHEM (CN) 1995-12-13 — — CN claimed
CN-113321639-B Method for preparing polysubstituted isoquinolone derivative 中国科学院大连化学物理研究所 2022-06-28 — — CN disclosed
CN-113321639-A Method for preparing polysubstituted isoquinolone derivative 中国科学院大连化学物理研究所 2021-08-31 — — CN disclosed
US-20200199261-A1 HIGHLY SENSITIVE OXIME ESTER PHOTOPOLYMERIZATION INITIATOR AND PHOTOPOLYMERIZABLE COMPOSITION INCLUDING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2020-06-25 — — US disclosed
CN-110392687-A Crystalline forms of salts of fused tetracyclic or pentacyclic dihydrodiaza-carbazolones and uses thereof 百济神州有限公司 2019-10-29 — — CN disclosed
CN-110392687-A Crystalline forms of salts of fused tetracyclic or pentacyclic dihydrodiaza-carbazolones and uses thereof 百济神州有限公司 2019-10-29 — — CN disclosed
CN-109862904-A BACITRACIN-ALGINATE OLIGOMER CONJUGATES 阿尔吉法玛公司 2019-06-07 — — CN disclosed
CN-1107474-A Method for preparing tetrahydro-carbazolone derivative SIDA BIOLOG TECH I BEIJING (CN) 1995-08-30 — — CN disclosed
CN-1105364-A Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazole-1-yl)methyl]-4H-carbazole-4-one compound QILU PHARMACEUTICAL FACTORY (CN) 1995-07-19 — — CN disclosed
CN-1089941-A Carbazolone derivatives and preparation method thereof RICHTER GEDEON VEGYESZET (HU) 1994-07-27 — — CN disclosed
CN-1020101-C Process for preparation of tricycle kentones GLAXO GROUP LTD (GB) 1993-03-17 — — CN disclosed
CN-87107308-A Process for preparing tricyclic ketones — 1988-06-08 — — CN disclosed
US-3962451-A ANTIVIRAL RICHARDSON-MERRELL INC. (US) 1976-06-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200199261-A1 HIGHLY SENSITIVE OXIME ESTER PHOTOPOLYMERIZATION INITIATOR AND PHOTOPOLYMERIZABLE COMPOSITION INCLUDING THE SAME LCLAT1, LPO, PLOD2 PBRM1 903/4885KIF11 4042/4885PIM3 915/4885
US-20050262647-A1 Agent for dyeing fibers containing keratin KRT18, CKAP4, KRTCAP2 PBRM1 1946/4885KIF11 410/4885PIM3 4399/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.