Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.58 |
| ▸ | HTR6 | P50406 | 8/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13979604 | 0.88 | SIRT1 (0.68) | SIRT1HTR6HTR2AHTR7ADRA2A | |
| SCHEMBL4656461 | 0.82 | HTR6 (0.70) | SIRT1HTR6HTR2AHTR7ADRA2A | |
| SCHEMBL26989650 | 0.82 | HTR6 (0.68) | SIRT1HTR6HTR2ATRPM8HTR7 | |
| SCHEMBL28750432 | 0.81 | HTR6 (0.68) | SIRT1HTR6HTR2ATRPM8HTR7 | |
| Hydrochloric Acid SCHEMBL892350 | 0.80 | HTR6 (0.67) | SIRT1HTR6HTR2ATRPM8HTR7 | |
| SCHEMBL8691195 | 0.79 | HTR6 (0.71) | HTR6HTR2ATRPM8HTR7HTR1D | |
| SCHEMBL8758888 | 0.78 | SIRT1 (0.46) | SIRT1HTR6HTR2ATRPM8HTR7 | |
| Cyanide SCHEMBL28561199 | 0.78 | HTR6 (0.63) | SIRT1HTR6HTR2ATRPM8HTR7 | |
| SCHEMBL3886866 | 0.78 | HTR6 (0.63) | HTR6HTR2AHTR7HTR1DHTR2C | |
| Hydrochloric Acid SCHEMBL275390 | 0.76 | HTR6 (0.61) | HTR6HTR2AHTR7HTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404317-B1 | 5-HALO-TRYPTAMINE DERIVATIVES USED AS LIGANDS OF THE 5-HT 6? AND/OR 5-HT 7? SEROTONIN RECEPTORS | SIGMA TAU IND FARMACEUTI (IT) | 2008-12-10 | — | — | EP | disclosed |
| US-7098233-B2 | 5-halo-tryptamine derivatives used as ligands on the 5-HT6 and/or 5-HT7 serotonin receptors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-08-29 | — | — | US | disclosed |
| US-20040235899-A1 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-11-25 | — | — | US | disclosed |
| EP-1404317-A1 | 5-HALO-TRYPTAMINE DERIVATIVES USED AS LIGANDS OF THE 5-HT 6? AND/OR 5-HT 7? SEROTONIN RECEPTORS | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000252-A1 | 5-HALO-TRYPTAMINE DERIVATIVES USED AS LIGANDS OF THE 5-HT6 AND/OR 5-HT7 SEROTONIN RECEPTORS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235899-A1 | 5-halo-tryptamine derivatives used as ligands of the 5-ht6 and/or 5-ht7 serotonin receptors | HTR7, HTR6, HTR1A | SIRT1 3427/4885HTR6 2/4885HTR2A 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.