Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.72 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.72 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.72 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.72 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.72 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.72 |
| ▸ | THRB | P10828 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 4/20 | 0.72 |
| ▸ | TP53 | P04637 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.72 |
| ▸ | SNCA | P37840 | 3/20 | 0.72 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.72 |
| ▸ | RECQL | P46063 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656550 | 1.00 | MEN1 (0.72) | MEN1KMT2AMAPK1TDP1THRB | |
| Brilliant Green SCHEMBL28216 | 0.85 | TDP1 (0.88) | MEN1KMT2AMAPK1TDP1THRB | |
| Hexamethyl Pararosaniline SCHEMBL9171 | 0.85 | TDP1 (1.00) | MEN1KMT2AMAPK1TDP1THRB | |
| Brilliant Green SCHEMBL171205 | 0.83 | TDP1 (0.84) | MEN1KMT2AMAPK1TDP1THRB | |
| Hexamethyl Pararosaniline SCHEMBL94116 | 0.83 | TDP1 (0.96) | MEN1KMT2AMAPK1TDP1THRB | |
| SCHEMBL4655638 | 0.81 | MAPT (0.85) | MEN1KMT2AMAPK1TDP1THRB | |
| SCHEMBL4657906 | 0.79 | MAPK1 (0.63) | MEN1KMT2AMAPK1TDP1THRB | |
| SCHEMBL4655651 | 0.78 | KMT2A (0.74) | MEN1KMT2AMAPK1TDP1THRB | |
| SCHEMBL14310873 | 0.78 | TDP1 (0.84) | MEN1KMT2AMAPK1TDP1THRB | |
| Hydrochloric Acid SCHEMBL30368330 | 0.77 | TDP1 (0.72) | MEN1KMT2AMAPK1TDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435227-B1 | Composition for the dyeing of keratinous fibres comprising a direct dye of the monoheteroyldiarylmethane type or a leuco precursor thereof and a dyeing process using it | OREAL (FR) | 2008-12-03 | — | — | EP | claimed |
| US-7211117-B2 | Composition for dyeing keratin fibers comprising at least one dye chosen from monoheteroyldiarylmethane direct dyes and the leuco precursors thereof and dyeing method using it | L'OREAL S.A. (FR) | 2007-05-01 | — | — | US | claimed |
| US-20040216247-A1 | Composition for dyeing keratin fibers comprising at least one dye chosen from monoheteroyldiarylmethane direct dyes and the leuco precursors thereof and dyeing method using it | L'OREAL S.A. (FR) | 2004-11-04 | — | — | US | claimed |
| US-7211117-B2 | Composition for dyeing keratin fibers comprising at least one dye chosen from monoheteroyldiarylmethane direct dyes and the leuco precursors thereof and dyeing method using it | L'OREAL S.A. (FR) | 2007-05-01 | — | — | US | disclosed |
| US-20040216247-A1 | Composition for dyeing keratin fibers comprising at least one dye chosen from monoheteroyldiarylmethane direct dyes and the leuco precursors thereof and dyeing method using it | L'OREAL S.A. (FR) | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040216247-A1 | Composition for dyeing keratin fibers comprising at least one dye chosen from monoheteroyldiarylmethane direct dyes and the leuco precursors thereof and dyeing method using it | KRT18, KMO, PLOD3 | CHRM2 3658/4885CHRM1 3720/4885CHRM3 3047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.