Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071032 | 0.86 | MEN1 (0.45) | POLBHCAR1TP53MEN1KMT2A | |
| SCHEMBL2069197 | 0.85 | KDM4E (0.47) | POLBHCAR1TP53MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2070338 | 0.81 | HCAR1 (0.44) | POLBHCAR1TP53MEN1KMT2A | |
| SCHEMBL2070675 | 0.80 | GABRG2 (0.46) | POLBHCAR1TP53MEN1KMT2A | |
| SCHEMBL2070757 | 0.69 | NPSR1 (0.38) | POLBHCAR1TP53MEN1KMT2A | |
| SCHEMBL18268478 | 0.68 | LMNA (0.61) | POLBHCAR1TP53MEN1KMT2A | |
| SCHEMBL213156 | 0.66 | LMNA (0.46) | POLBTP53MEN1KMT2ALMNA | |
| SCHEMBL9352393 | 0.65 | HSD11B1 (0.55) | POLBTP53MEN1KMT2AMAPT | |
| SCHEMBL27200164 | 0.63 | HCAR1 (0.45) | POLBHCAR1TP53MEN1KMT2A | |
| SCHEMBL24945058 | 0.63 | ALDH1A1 (0.65) | POLBTP53MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |