Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.58 |
| ▸ | CDC25B | P30305 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | IDO1 | P14902 | 3/20 | 0.58 |
| ▸ | MAOA | P21397 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 3/20 | 0.58 |
| ▸ | CDC25A | P30304 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.58 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.58 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | SNCA | P37840 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052798 | 0.80 | PTPN1 (0.58) | MAPTMAPK1CDC25BLMNAMEN1 | |
| SCHEMBL6555840 | 0.77 | BACE1 (0.75) | MAPTMAPK1CDC25BLMNAMEN1 | |
| Menadione SCHEMBL1364028 | 0.73 | MAPT (1.00) | MAPTMAPK1CDC25BLMNAMEN1 | |
| Menadione SCHEMBL19356853 | 0.73 | MAPT (1.00) | MAPTMAPK1CDC25BLMNAMEN1 | |
| Menadione SCHEMBL25970 | 0.73 | MAPT (1.00) | MAPTMAPK1CDC25BLMNAMEN1 | |
| SCHEMBL25358615 | 0.73 | MAPT (0.56) | MAPTMAPK1CDC25BLMNAMEN1 | |
| SCHEMBL14763777 | 0.73 | MAPT (0.56) | MAPTMAPK1CDC25BLMNAMEN1 | |
| SCHEMBL125298 | 0.73 | CDC25B (0.56) | MAPTMAPK1CDC25BLMNAMEN1 | |
| Lawsone SCHEMBL6849999 | 0.73 | MAPT (0.68) | MAPTMAPK1CDC25BLMNAMEN1 | |
| Lawsone SCHEMBL16541 | 0.73 | MAPT (0.68) | MAPTMAPK1CDC25BLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105646300-A | Method for preparing 2-octyl sulfoxide-1,4-naphthoquinone | 黑龙江八农垦大学 | 2016-06-08 | — | — | CN | disclosed |
| EP-1567515-A4 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1567515-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | HINES GLOBAL EDUCATION | 2004-12-30 | — | — | US | disclosed |
| WO-2004045557-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | XIAP, MKI67, PIN1 | MAPT 3021/4885MAPK1 1088/4885CDC25B 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.