Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | METAP2 | P50579 | 5/20 | 0.47 |
| ▸ | METAP1 | P53582 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545018 | 0.85 | METAP2 (0.49) | HDAC3HDAC1HDAC2METAP2METAP1 | |
| SCHEMBL4267098 | 0.82 | METAP2 (0.51) | HDAC3HDAC1HDAC2METAP2METAP1 | |
| SCHEMBL8490097 | 0.82 | ALDH1A1 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2DPP8 | |
| Bromide SCHEMBL5891506 | 0.79 | SMN1; SMN2 (0.55) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL985997 | 0.79 | LARS1 (0.58) | HDAC3HDAC1HDAC2METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL8669233 | 0.78 | LARS1 (0.57) | HDAC3HDAC1HDAC2METAP2METAP1 | |
| Cystine SCHEMBL9132888 | 0.76 | METAP2 (0.47) | HDAC3HDAC1HDAC2METAP2METAP1 | |
| SCHEMBL7043430 | 0.76 | METAP2 (0.46) | HDAC3HDAC1HDAC2METAP2METAP1 | |
| SCHEMBL9390095 | 0.75 | METAP2 (0.49) | HDAC3HDAC1HDAC2METAP2NPC1 | |
| SCHEMBL6828289 | 0.74 | NAMPT (0.57) | METAP2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1018345-B1 | WATER SOLUBLE DRY COMPOSITIONS | OTSUKA PHARMA CO LTD (JP) | 2008-12-10 | — | — | EP | disclosed |
| EP-1254944-B1 | DRY COMPOSITIONS CONTAINING HYDROPHOBIC AMINO ACID | OTSUKA PHARMA CO LTD (JP) | 2007-03-28 | — | — | EP | disclosed |
| US-20030045481-A1 | Dry compositions containing hydrophobic amino acid | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-06 | — | — | US | disclosed |
| US-6479048-B2 | FOAM INHIBITOR COMPRISING HYDROPHOBIC AMINO ACID WHICH IS SUITABLE FOR INHIBITING FOAMING INDUCED WHEN DISSOLVING A DRY COMPOSITION CONTAINING SACCHARIDE; PREFERABLY HAS A HYDROPATHY INDEX OF NOT LESS THAN 2. | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-12 | — | — | US | disclosed |
| EP-1254944-A1 | DRY COMPOSITIONS CONTAINING HYDROPHOBIC AMINO ACID | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-06 | — | — | EP | disclosed |
| US-6337067-B1 | FOR INHIBITING FOAMING CAUSED WHEN DISSOLVING A CONVENTIONAL DRY COMPOSITION CONTAINING A SACCHARIDE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-01-08 | — | — | US | disclosed |
| US-20010049361-A1 | Water-soluble dry compositions | OTSUKA PHARMACEUTICAL CO., LTD. | 2001-12-06 | — | — | US | disclosed |
| EP-1018345-A1 | WATER SOLUBLE DRY COMPOSITIONS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-12 | — | — | EP | disclosed |