Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25B | P30305 | 5/20 | 0.56 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.56 |
| ▸ | CDC25A | P30304 | 3/20 | 0.56 |
| ▸ | S100A4 | P26447 | 5/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 2/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GALK1 | P51570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17445488 | 0.79 | CDC25B (0.78) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL4629512 | 0.77 | S100A4 (0.76) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL4784115 | 0.75 | PTPRC (0.50) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL18191031 | 0.72 | CDC25B (1.00) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL31745097 | 0.72 | CDC25B (1.00) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL17445487 | 0.71 | SOAT1 (0.51) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL4848419 | 0.70 | SOAT1 (0.78) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL2599351 | 0.67 | S100A4 (1.00) | CDC25BMAP2K7CDC25AS100A4SOAT1 | |
| SCHEMBL11569786 | 0.64 | FFAR1 (0.60) | ALDH1A1MAPTHPGDMAPK1MEN1 | |
| SCHEMBL2599403 | 0.63 | S100A4 (1.00) | CDC25BMAP2K7CDC25AS100A4SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567515-A4 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1567515-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | HINES GLOBAL EDUCATION | 2004-12-30 | — | — | US | disclosed |
| WO-2004045557-A2 | NOVEL LAPACHONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266857-A1 | Novel lapachone compounds and methods of use thereof | XIAP, MKI67, PIN1 | CDC25B 143/4885MAP2K7 1605/4885CDC25A 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.