Sugi Predict

Sugi Predict / Compounds / SCHEMBL465792

SCHEMBL465792

SCHEMBL465792

CC(C)(C)OC(=O)Nc1cccc(CO)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCR2 P41597 1/20 0.42
▸ SCN9A Q15858 3/20 0.42
▸ LCK P06239 2/20 0.41
▸ GRM5 P41594 1/20 0.40
▸ NR3C2 P08235 1/20 0.40
▸ CHRNB2 P17787 1/20 0.40
▸ CHRNB4 P30926 1/20 0.40
▸ CHRNA3 P32297 1/20 0.40
▸ CHRNA4 P43681 1/20 0.40
▸ CYP17A1 P05093 1/20 0.39
▸ GLS O94925 1/20 0.39
▸ RAB9A P51151 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ CDK5 Q00535 1/20 0.39
▸ CDK5R1 Q15078 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MAPK8 P45983 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30396325 1.00 CCR2 (0.42) CCR2SCN9ALCKGRM5NR3C2
SCHEMBL6320838 0.89 NR3C2 (0.43) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL4076010 0.88 CHRNB2 (0.51) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL29988292 0.87 GLS (0.42) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL2827164 0.87 GLS (0.42) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL8307596 0.87 CCR2 (0.44) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL6681771 0.87 CCR2 (0.42) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL1022260 0.87 GLS (0.42) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL21198393 0.87 CCR2 (0.42) CCR2SCN9ALCKNR3C2CHRNB2
SCHEMBL29394473 0.86 LCK (0.47) LCKRAB9AMEN1NPC1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5948792-A POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-09-07 — — US claimed
EP-0930298-A1 FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-07-21 — — EP claimed
WO-2023171593-A1 METHOD FOR REDUCING OR PREVENTING EFFECT OF SALT STRESS ON PLANT 日本曹達株式会社 2023-09-14 — — WO disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 — — WO disclosed
US-11641858-B2 Agricultural chemicals REDAG CROP PROTECTION LTD. (GB) 2023-05-09 — — US disclosed
US-11641858-B2 Agricultural chemicals REDAG CROP PROTECTION LTD. (GB) 2023-05-09 — — US disclosed
WO-2022125412-A1 TETRAHYDROQUINAZOLINE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS MERCK SHARP & DOHME CORP. (US) 2022-06-16 — — WO disclosed
US-11224224-B2 Thiobenzoimidazole as fungicides REDAG CROP PROTECTION LTD. (GB) 2022-01-18 — — US disclosed
WO-2021262628-A1 POLY HETEROCYCLIC CONJUGATES AND THEIR PHARMACEUTICAL USES NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2021-12-30 — — WO disclosed
US-20210403483-A1 POLY HETEROCYCLIC CONJUGATES AND THEIR PHARMACEUTICAL USES NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2021-12-30 — — US disclosed
EP-3442961-B1 AGRICULTURAL CHEMICALS REDAG CROP PROT LTD (GB) 2021-03-24 — — EP disclosed
US-20060160857-A1 Thiazole-4-carboxyamide derivatives HOFFMANN-LA ROCHE INC. 2006-07-20 — — US disclosed
WO-2006074884-A1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2006-07-20 — — WO disclosed
WO-2006074884-A1 THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2006-07-20 — — WO disclosed
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-03-25 — — US disclosed
EP-0930298-B1 FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES BANYU PHARMA CO LTD (JP) 2002-12-18 — — EP disclosed
JP-2000169449-A NEW PRODUCTION INTERMEDIATE FOR FLUORINE-CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVE BANYU PHARMACEUT CO LTD 2000-06-20 — — JP disclosed
US-6040449-A USEFUL FOR FORMING FLUORINE CONTAINING 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES, USEFUL AS ANTAGONIST FOR MUSCARINIC M3 RECEPTORS AND LESS SIDE EFFECT BANYU PHARMACEUTICAL CO LTD (JP) 2000-03-21 — — US disclosed
US-5948792-A POTENT AND SELECTIVE ANTAGONISTS FOR MUSCARINIC M.SUB.3 RECEPTORS WITH LITTLE SIDE EFFECTS. BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-09-07 — — US disclosed
EP-0930298-A1 FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES BANYU PHARMACEUTICAL CO., LTD. (JP) 1999-07-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11224224-B2 Thiobenzoimidazole as fungicides CYP1B1, CYP51A1, CYP1A2 CCR2 4100/4885SCN9A 1283/4885LCK 2443/4885
US-20060160857-A1 Thiazole-4-carboxyamide derivatives GRM1, GRM2, GRIA4 CCR2 537/4885SCN9A 1847/4885LCK 2212/4885
US-20210403483-A1 POLY HETEROCYCLIC CONJUGATES AND THEIR PHARMACEUTICAL USES H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, GAA, UGT2B7 CCR2 3320/4885SCN9A 3175/4885LCK 1808/4885
US-20040058903-A1 Benzamide compounds as apo b secretion inhibitors APOB, APOL1, SCARB1 CCR2 799/4885SCN9A 718/4885LCK 3867/4885
US-11641858-B2 Agricultural chemicals DDT, CYP4X1, CYP1A2 CCR2 2687/4885SCN9A 3816/4885LCK 2704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.