Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.46 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909911 | 0.84 | MEN1 (0.56) | ELANEALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL6846654 | 0.84 | KMT2A (0.51) | ELANEALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL17478740 | 0.84 | KMT2A (0.52) | ELANEALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL2910393 | 0.83 | ALDH1A1 (0.67) | ELANEALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL6596709 | 0.80 | ALDH1A1 (0.47) | ELANEALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL29230151 | 0.80 | ELANE (0.45) | ELANEALDH1A1TXNRD1TXNRD3TXNRD2 | |
| SCHEMBL1257817 | 0.80 | ELANE (0.72) | ELANEALDH1A1OPRK1KMT2ASMN1; SMN2 | |
| SCHEMBL17478755 | 0.80 | ALDH1A1 (0.71) | ELANEALDH1A1KMT2AABCG2 | |
| SCHEMBL6201684 | 0.78 | KDM4E (0.50) | ELANEALDH1A1KMT2AHPGD | |
| SCHEMBL27258600 | 0.77 | ALDH1A1 (0.53) | ELANEALDH1A1KMT2ATP53ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125372-A1 | DYNAMIN-1-LIKE PROTEIN INHIBITORS AND USES THEREOF | ASTELLAS ENG SMALL MOLECULES US INCORPORATED (US) | 2026-05-07 | — | — | US | disclosed |
| EP-4608825-A1 | FUSED AZINES AS DYNAMIN-1-LIKE PROTEIN INHIBITORS AND USES THEREOF | Astellas Engineered Small Molecules US, Incorporated (US) | 2025-09-03 | — | — | EP | disclosed |
| CN-120077039-A | Fusion azines as dynamin-1 like protein inhibitors and uses thereof | 安斯泰来工程小分子美国股份有限公司 | 2025-05-30 | — | — | CN | disclosed |
| WO-2024091489-A1 | FUSED AZINES AS DYNAMIN-1-LIKE PROTEIN INHIBITORS AND USES THEREOF | MITOBRIDGE, INC. (US) | 2024-05-02 | — | — | WO | disclosed |
| EP-1819342-A4 | QUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-12-17 | — | — | EP | disclosed |
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2007-12-20 | — | — | US | disclosed |
| EP-1819342-A1 | QUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006060390-A1 | QUINOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20050165006-A1 | Quinoline derivatives, their preparation and pharmaceutical compositions comprising the same | HYUNDAI PHARM. IND. CO., LTD. (KR) | 2005-07-28 | — | — | US | disclosed |
| EP-1373252-A1 | CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT | Aventis Pharma S.A. (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2003082286-A1 | QUINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | CHEMON INC. (KR) | 2003-10-09 | — | — | WO | disclosed |
| WO-2002076975-A1 | CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT | AVENTIS PHARMA S.A. (FR) | 2002-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165006-A1 | Quinoline derivatives, their preparation and pharmaceutical compositions comprising the same | SLC18A2, SLC6A4, SLC6A2 | ELANE 4879/4885ALDH1A1 3497/4885TXNRD1 707/4885 |
| US-20070293492-A1 | Quinoline Tachykinin Receptor Antagonists | TACR1, TACR2, NPSR1 | ELANE 1070/4885ALDH1A1 874/4885TXNRD1 2666/4885 |
| US-20260125372-A1 | DYNAMIN-1-LIKE PROTEIN INHIBITORS AND USES THEREOF | DNM1L, DNM1, DNM2 | ELANE 3152/4885ALDH1A1 4578/4885TXNRD1 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.