Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MPL | P40238 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL465715 | 0.88 | LMNA (0.52) | MAPTTP53LMNAKDM4EAKT1 | |
| SCHEMBL12029085 | 0.81 | GLA (0.43) | MAPTTP53ELANEKDM4ECFTR | |
| SCHEMBL9980808 | 0.77 | FBP1 (0.51) | PIN1MAPTPARP1 | |
| SCHEMBL465918 | 0.77 | FBP1 (0.51) | PIN1MAPTPARP1 | |
| SCHEMBL13419133 | 0.74 | PIN1 (0.44) | PIN1KDM4EMAPK14PARP1PIM1 | |
| SCHEMBL30285066 | 0.71 | RORB (0.61) | CFTRKDRGSK3BCYP1A2CYP2C19 | |
| SCHEMBL12427050 | 0.71 | CFTR (0.52) | PIN1MAPTKDM4ECFTRMAPK14 | |
| SCHEMBL9980770 | 0.71 | DHODH (0.46) | PIN1MAPTLMNAKDM4EPARP1 | |
| SCHEMBL8624640 | 0.70 | PARP1 (0.73) | PIN1PARP1 | |
| SCHEMBL465897 | 0.70 | PPARG (0.51) | MAPTTP53LMNAKDM4ECFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344475-A1 | QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010037129-A1 | QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS INC. (US) | 2010-04-01 | — | — | WO | disclosed |