SCHEMBL4660153

SCHEMBL4660153

CCC(C#N)(C(=O)O)C(c1ccccc1SC)c1cccc2ccccc12

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
HPGD P15428 2/20 0.35
HTT P42858 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
ALDH1A1 P00352 2/20 0.34
LMNA P02545 2/20 0.34
HSP90AA1 P07900 1/20 0.34
MAPT P10636 1/20 0.34
RECQL P46063 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
SLC22A12 Q96S37 1/20 0.34
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
CYP1A2 P05177 1/20 0.33
ACP3 P15309 1/20 0.33
EPHX2 P34913 2/20 0.33
KMT2A Q03164 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4661436 0.85 MEN1 (0.36) PPARGPPARAHPGDHTTCYP2C9
SCHEMBL4662654 0.85 PPARG (0.38) PPARGPPARAHPGDHTTCYP2C9
SCHEMBL4661396 0.85 PPARG (0.38) PPARGPPARAHPGDHTTCYP2C9
SCHEMBL4661491 0.84 ESR1 (0.40) HPGDHTTCYP2C9CYP2C19ALDH1A1
SCHEMBL4661407 0.83 PPARG (0.46) PPARGPPARAHPGDHTTCYP2C9
SCHEMBL4661587 0.83 ESR1 (0.45) PPARGPPARAHPGDHTTALDH1A1
SCHEMBL4660186 0.81 PPARG (0.37) PPARGPPARAHPGDHTTCYP2C9
SCHEMBL4660128 0.81 ACP3 (0.42) PPARGPPARAHPGDHTTCYP2C9
SCHEMBL4661474 0.80 ALDH1A1 (0.42) PPARGPPARAALDH1A1MAPTSMN1; SMN2
SCHEMBL4661534 0.80 CMA1 (0.39) PPARGPPARAHPGDHTTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1620102-B1 3-(1-NAPHTHYL)-2-CYANOPROPANOIC ACID DERIVATIVES AS ESTROGEN RECEPTOR LIGANDS WYETH CORP (US) 2008-12-24 EP claimed