Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24030143 | 0.85 | L3MBTL1 (0.41) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL1855608 | 0.82 | CA2 (0.41) | KMT2AMEN1TDP1ALDH1A1GAA | |
| SCHEMBL3548649 | 0.82 | ALDH1A1 (0.33) | L3MBTL1KMT2AMEN1TDP1ALDH1A1 | |
| SCHEMBL14174873 | 0.79 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4630504 | 0.77 | ATM (0.50) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL18909342 | 0.77 | L3MBTL1 (0.42) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL21022559 | 0.76 | L3MBTL1 (0.35) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL14174881 | 0.76 | GNAI3 (0.46) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL792228 | 0.76 | KMT2A (0.48) | L3MBTL1KMT2AMEN1TDP1ATM | |
| SCHEMBL791911 | 0.76 | KMT2A (0.48) | L3MBTL1KMT2AMEN1TDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |