Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.71 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CA12 | O43570 | 1/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | CA9 | Q16790 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660687 | 0.90 | ALDH1A1 (0.73) | CYP19A1KEAP1CYP1A2CYP3A4CA12 | |
| SCHEMBL21048461 | 0.88 | KEAP1 (0.81) | CYP19A1KEAP1CYP1A2CYP3A4CA12 | |
| SCHEMBL13637468 | 0.85 | CYP19A1 (0.64) | CYP19A1KEAP1CYP1A2CYP3A4CA12 | |
| SCHEMBL3564279 | 0.84 | CYP19A1 (0.67) | CYP19A1CYP1A2CYP3A4CA12ATM | |
| SCHEMBL407414 | 0.82 | KEAP1 (1.00) | KEAP1CYP1A2CYP3A4CA12ATM | |
| SCHEMBL13637461 | 0.82 | CYP19A1 (0.59) | CYP19A1CYP1A2CYP3A4CA12ATM | |
| SCHEMBL198318 | 0.81 | CA12 (1.00) | CYP19A1KEAP1CYP1A2CYP3A4CA12 | |
| SCHEMBL4662819 | 0.81 | CA12 (0.87) | CYP19A1KEAP1CYP1A2CYP3A4CA12 | |
| Hydrochloric Acid SCHEMBL3516799 | 0.81 | KEAP1 (0.96) | KEAP1CYP1A2CYP3A4CA12ATM | |
| SCHEMBL4662812 | 0.81 | CYP19A1 (0.71) | CYP19A1KEAP1CYP1A2CYP3A4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007760-A1 | NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007108569-A1 | NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2007-09-27 | — | — | WO | disclosed |